Chicago police said they tried to stop a black Chrysler in the 10700 block of South Michigan Avenue at about 8:45 p.m. Police said the driver took off from police and collided head-on with a white Acura in the 10700 block of South Calumet Avenue.
The suspect then rammed into a tree and the 2-year-old girl was ejected from the vehicle, police said. She was transported to a hospital, where she later died.
Police said the girl was not in a car seat. Authorities have not released her name.
Four other people who were inside the two cars were also injured and were hospitalized in stable condition.
The 21-year-old man driving the Chrysler was arrested at the scene. Officers said they found a weapon inside of the car.